Current Research and Opportunities to Participate
The NNL is currently working with study teams who are investigating various types of conditions, including OCD, major depressive disorder, traumatic brain injuries, Parkinson's disease, and many others. Below is a list of studies that we currently support or are apart of. Click the links provided to learn more about each of them.
Pediatric Studies
Inhibitory Mechanisms of Negative Urgency in Adolescent Suicidal Behavior and Neurometabolite Markers of Suicide-Related Cognition in Adolescents (Ages 13-21)
The goal of this study is to utilize both EEG and neuronavigated TMS (called closed-loop TMS-EEG) to examine the neural pathways of individuals ages 13-21 with depression who have ever had either thoughts about suicide or suicidal behaviors.
Transcranial Magnetic Stimulation to Augment Exposure and Response Prevention for Pediatric OCD (NExT Study) (Ages 12-21)
NExT is a multisite trial using neuronavigated transcranial magnetic stimulation (TMS) with Exposure and Response Prevention (ERP) for individuals age 12-21 who experience symptoms of OCD.
Adult Studies
Control Network Neuromodulation to Enhance Cognitive Training in Complex Traumatic Brain Injury (CONNECT-TBI) (Ages 18-59)
CONNECT-TBI is a multisite trial comparing Transcranial Magnetic Stimulation (TMS) and Transcranial Direct Current Stimulation (tDCS) coupled with cognitive training tasks for US Veterans ages 18-59 who experienced a mild traumatic brain injury while serving.
RECODE Study
The goal of the RECODE study is to examine how cognition is affected by pain and depression. Using functional MRI and closed-loop TMS-EEG, the RECODE team hopes to locate individual neural pathways that may be impacted within each participant.
TMS x DPX Study (Ages 18-65)
This study aims to examine whether the benefits of brain stimulation on mental functioning can be enhanced if an individual is actively engaging the target brain networks while receiving the brain stimulation. Both EEG and neuronavigated TMS are utilized in this experiment.
Neuroplasticity and the Emergence of Motor and Cognitive Deficits in Prodromal Synucleinopathy
The goal of this study is to use functional magnetic resonance imaging (fMRI), neuronavigated TMS and EEG to better understand the neuroplastic changes in individuals with isolated rapid eye movement (REM) behavior sleep disorder and potential links to movement diseases.
Prefrontal Cortical Stimulation (PCS) for Severe Treatment-Resistant Depression (Ages 22-55)
The goal of this study is to test whether symptoms of depression can be treated by electrically stimulating the surface of the brain, specifically the parts of the brain right behind the forehead.